Resveratrol SC

Resveratrol is found in the skin of grapes, but also in other various plants. It is known as an antioxidant and got a lot of attention when a study on mice showed that resveratrol increased the lifespan of these animals in spite of being fed a high fat, high calorie diet (Baur JA, et al. 2006). Resveratrol was found to stimulate SIRT-1, one of the longevity genes. Some of the other changes also include improved insulin sensitivity, increased number of mitochondria (the energy producing entity of the cell) and improved motor function (they moved better).

When tested, both resveratrol and quercetin were found to be potent anti-inflammatory agents (Donnelly LE, et al, 2004, Takada Y, et al, 2004).

Resveratrol and quercetin have also demonstrated a dose-dependent inhibition of platelet aggregation (formation of blood cloths) which may prove protective benefits against atherosclerosis (Pace-Asciak CR, et al, 2005).

Resveratrol has shown to inhibit cancer in human cell lines including breast cancer (Roncoroni L, et al, 2008, Tang FY, et al, 2008, Le Corre L, et al, 2005).

Resveratrol has demonstrated antifungal activity against candida albicans (Jung HJ, et al, 2007).

Resveratrol has been documented to be able to modulate enzyme systems involved in carcinogen activation and detoxification, which may be one mechanism by which resveratrol inhibits carcinogens (Chow HH, et al. 2011).

This is all very exciting, but the problem with resveratrol is that it has low bioavailability, metabolic stability because it is eliminated quickly (Walle T, et al, 2004). That problem is however solved by using methylated resveratrol. When the resveratrol is methylated it has shown to have approximately 5-to-8-fold higher permeability meaning absorption and also increased bioavailability (Wen X, Walle T. 2006, Walle T, 2007).

Resveratrol SC is a methylated resveratrol formula for increased bioavailability which also includes quercetin.

Nutritional Facts:
Serving Size: 2 Capsules
Servings per container: 30
Quercetin 95%…………………………………………500 mg
Resveratrol (as Polygonum cuspidatum extract, 50%)…….150 mg
Methylated Resveratrol (Pterostilbene)…………………………125 mg

Other Ingredients: Rice Protein Powder, Microcrystaline Cellulose, Carboxy Methycellulose, Silica, Stearic Acid, and Magnesium Stearate.

References:

Donnelly LE, et al. Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms. Am J Physiol Lung Cell Mol Physiol. 2004 Oct;187(4):L774-83.

Jung HJ, et al. Candicidal action of resveratrol isolated from grapes on human pathogenic yeast C. albicans. J Microbiol Biotechnol. 2007 Aug;17(8):1324-9.

Takada Y, et al. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene. 2004 Dec 9; 23(57):9247-58.

Tang FY, et al. Resveratrol inhibits migration and invasion of human breast-cancer cells. Mol Nutr Food Res. 2008 Apr 8.

Walle T, et al. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos. 2004 Dec;32(12):1377-82.

Walle T. Methylation of dietary flavones greatly improves their hepatic metabolic stability and intestinal absorption. Mol Pharm. 2007 Nov-Dec;4(6):862-32.

Resveratrol is found in the skin of grapes, but also in other various plants. It is known as an antioxidant and got a lot of attention when a study on mice showed that resveratrol increased the lifespan of these animals in spite of being fed a high fat, high calorie diet (Baur JA, et al. 2006). Resveratrol was found to stimulate SIRT-1, one of the longevity genes. Some of the other changes also include improved insulin sensitivity, increased number of mitochondria (the energy producing entity of the cell) and improved motor function (they moved better).

When tested, both resveratrol and quercetin were found to be potent anti-inflammatory agents (Donnelly LE, et al, 2004, Takada Y, et al, 2004).

Resveratrol and quercetin have also demonstrated a dose-dependent inhibition of platelet aggregation (formation of blood cloths) which may prove protective benefits against atherosclerosis (Pace-Asciak CR, et al, 2005).

Resveratrol has shown to inhibit cancer in human cell lines including breast cancer (Roncoroni L, et al, 2008, Tang FY, et al, 2008, Le Corre L, et al, 2005).

Resveratrol has demonstrated antifungal activity against candida albicans (Jung HJ, et al, 2007).

Resveratrol has been documented to be able to modulate enzyme systems involved in carcinogen activation and detoxification, which may be one mechanism by which resveratrol inhibits carcinogens (Chow HH, et al. 2011).

This is all very exciting, but the problem with resveratrol is that it has low bioavailability, metabolic stability because it is eliminated quickly (Walle T, et al, 2004). That problem is however solved by using methylated resveratrol. When the resveratrol is methylated it has shown to have approximately 5-to-8-fold higher permeability meaning absorption and also increased bioavailability (Wen X, Walle T. 2006, Walle T, 2007).

Resveratrol SC is a methylated resveratrol formula for increased bioavailability which also includes quercetin.

Nutritional Facts:
Serving Size: 2 Capsules
Servings per container: 30
Quercetin 95%…………………………………………500 mg
Resveratrol (as Polygonum cuspidatum extract, 50%)…….150 mg
Methylated Resveratrol (Pterostilbene)…………………………125 mg

Other Ingredients: Rice Protein Powder, Microcrystaline Cellulose, Carboxy Methycellulose, Silica, Stearic Acid, and Magnesium Stearate.

References:

Donnelly LE, et al. Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms. Am J Physiol Lung Cell Mol Physiol. 2004 Oct;187(4):L774-83.

Jung HJ, et al. Candicidal action of resveratrol isolated from grapes on human pathogenic yeast C. albicans. J Microbiol Biotechnol. 2007 Aug;17(8):1324-9.

Takada Y, et al. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene. 2004 Dec 9; 23(57):9247-58.

Tang FY, et al. Resveratrol inhibits migration and invasion of human breast-cancer cells. Mol Nutr Food Res. 2008 Apr 8.

Walle T, et al. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos. 2004 Dec;32(12):1377-82.

Walle T. Methylation of dietary flavones greatly improves their hepatic metabolic stability and intestinal absorption. Mol Pharm. 2007 Nov-Dec;4(6):862-32.